Evaluation of the Effect of Delivery Mode on Methylation Changes in the Global DNA and the PTEN Gene

Objective: This study aimed to investigate the association between global DNA and PTEN gene methylation changes type of delivery. Material Methods: The included a total 129 pregnant women at >37th week pregnancy who had cesarean (CS) (n=62) or vaginal delivery (VD) (n=67) their infant's cord blood (n=129). 5-mC ELISA method performed analyses, while change analyses were conducted using methylation-specific polymerase chain reaction method. Results: in CS (Group 1) VD 2) groups infants found be 9.15±4.82, 10.6±5.09 (p=0.09); 11.3±6.78, 11.7±5.69 (p=0.75), respectively. Based on age, when examined under over 30, infants, differences both statistically significant (p=0.05, p=0.015). rates Group 1 (22.5%) higher than 2 (13.4%). (17.7%) those (14.9%). Conclusion: In this study, increase was determined mothers regarding based age. Our is also first showing gene-specific gene. findings are believed pioneer new studies positively contribute scientific research.